| Autor: |
Iskandrian, Abdulmassih S., Bemis, Charles E., Hakki, A.-Hamid, Panidis, Ioannis, Heo, Jaekyeong, Gerald Toole, J., Hua, Tsushung A., Allin, Douglas, Kane-Marsch, Sally |
| Zdroj: |
Journal of the American College of Cardiology; July 1986, Vol. 8 Issue: 1 p225-231, 7p |
| Abstrakt: |
This study examined the effect of esmolol, an ultrashort-acting beta-receptor blocker, in 10 patients with severe left ventricular dysfunction. Simultaneous hemodynamic and radionuclide angiographic measurements were obtained at incremental doses of esmolol (2,4, 8,12 and 16 mg/min). At a dose of 4 mg/min, esmolol produced bets blockade: a decrease in heart rate from 91 ± 4 to 83 ± 4 beats/min (p < 0.05) (mean ± SEM) and a decrease in systolic aortic pressure from 133 ± 5 to 128 ± 5 mm Hg (p < 0.05). At the maximal dose, the heart rate decreased to 79 ± 3 beats/min (p < 0.05) and biventricular function was depressed; the left ventricular ejection fraction decreased from 27 ± 2 to 21 ± 2% (p < 0.05) and the right ventricular ejection fraction decreased from 38 ± 2 to 29 ± 2% (p < 0.05). These changes were accompanied by increases in left ventricular end-diastolic volume (p < 0.05), left ventricular end-systolic volume (p < 0.05) and pulmonary artery wedge pressure (p < 0.05), as well as a decrease in cardiac output (p < 0.05). The hemodynamic abnormalities (which showed considerable interindividual variability) returned to near baseline levels 10 to 30 minutes after infusion was stopped. |
| Databáze: |
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