Pharmacokinetic differences between peripheral and central drug administration during cardiopulmonary resuscitation

Autor: Talit, Uzi, Braun, Shimon, Halkin, Hillel, Shargorodsky, Boris, Laniado, Shlomo
Zdroj: Journal of the American College of Cardiology; November 1985, Vol. 6 Issue: 5 p1073-1077, 5p
Abstrakt: Advanced resuscitation techniques are dependent on drug therapy to increase survival. Because drugs must reach their site of action instantaneously, the choice of appropriate route of administration may be critical. To study the pharmacokinetics of drug administration by peripheral and central venous routes during resuscitation, nine mongrel dogs were studied. Arterial blood pressure and electrocardiograms were monitored continuously. Cardiac output was evaluated before resuscitation to determine control levels. After thoracotomy and fibrillation of the heart, cardiac massage was started with a frequency of compression maintained at 60/min.
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