Medical and surgical management of early Q wave myocardial infarction. I. Effects of surgical reperfusion on survival, recurrent myocardial infarction, sudden death and functional class at 10 or more years of follow-up

Autor: Dewood, Marcus A., Notske, Robert N., Berg, Ralph, Ganji, John H., Simpson, Carroll S., Hinnen, Michael L., Selinger, Samuel L., Fisher, Lloyd D.
Zdroj: Journal of the American College of Cardiology; July 1989, Vol. 14 Issue: 1 p65-77, 13p
Abstrakt: To define the outcome of patients given medical or surgical therapy for Q wave myocardial infarction, 387 patients were followed up for 10 to 13 years (mean 11.4). On study entry the groups had similar distributions for variables such as mean age, gender, previous myocardial infarction, abnormal creatine kinase activity, area of infarction, number of vessels diseased and clinical classification. The hospital mortality rate of the medical versus surgical group was 11.5% (23 of 200) versus 5.8% (11 of 187) (p = 0.07). Early reperfusion (that is, ≤6 h) resulted in a lower mortality rate than did medical therapy—2% (2 of 100) versus 11.5% (23 of 200) (p < 0.05)—whereas the hospital mortality rate with late reperfusion was 10.3% (9 of 87). The long-term mortality rate of the medical and surgical groups was 41% (82 of 200) versus 27% (51 of 187) (p = 0.0007) with use of an adjusted Cox proportional hazards model.
Databáze: Supplemental Index