| Autor: |
Schwaiger, Markus, Neese, Richard A., Araujo, Louis, Wyns, William, Wisneski, Judith A., Sochor, Heinz, Swank, Stanley, Kulber, David, Selin, Carl, Phelps, Michael, Schelbert, Heinrich R., Fishbein, Michael C., Gertz, Edward W., Hansen, Herbert |
| Zdroj: |
Journal of the American College of Cardiology; March 1989, Vol. 13 Issue: 3 p745-754, 10p |
| Abstrakt: |
Ischemically injured reperfused myocardium is characterized by increased 18F-fluorodeoxyglucose uptake as demonstrated by positron emission tomography. To elucidate the metabolic fate of exogenous glucose entering reperfused myocardium, D-[6-14C] glucose and L-[U-13C] lactate were used to determine glucose uptake, glucose oxidation and the contribution of exogenous glucose to lactate production. The pathologic model under investigation consisted of a 3 h balloon occlusion of the left anterior descending coronary artery followed by 24 h of reperfusion in canine myocardium. The extent and severity of myocardial injury after the ischemia and reperfusion were assessed by histochemical evaluation (triphenyltetrazolium chloride and periodic acid-Schiff stains). Thirteen intervention and four control dogs were studied. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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