| Autor: |
Borow, Kenneth M., Neumann, Alex, Arensman, Frederick W., Yacoub, Magdi H. |
| Zdroj: |
Journal of the American College of Cardiology; November 1989, Vol. 14 Issue: 5 p1229-1238, 10p |
| Abstrakt: |
A denervated heart coupled to a periphery previously exposed to high catecholamine levels provides a unique model to study adrenoceptor physiology. Six orthotopic transplant patients (1.3 ± 0.8 years postoperative) were age matched with six atropine-treated normal subjects. Simultaneous two-dimensionally targeted left ventricular echocardiograms and calibrated carotid pulse tracings were recorded. Left ventricular contractility was assessed with use of heart rate- and load-independent end-systolic indexes. Studies were performed at baseline and during dobutamine infusion with and without beta-adrenergic blockade with use of propranolol; effects were assessed during afterload changes generated by the alpha, agonist methoxamine. |
| Databáze: |
Supplemental Index |
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