Type 1 fiber abnormalities in skeletal muscle of patients with hypertrophic and dilated cardiomyopathy: Evidence of subclinical myogenic myopathy

Autor: Caforio, Alida L.P., Rossi, Bruno, Risaliti, Riccardo, Siciliano, Gabriele, Marchetti, Antonio, Angelini, Corrado, Crea, Filippo, Mariani, Mario, Muratorio, Alberto
Zdroj: Journal of the American College of Cardiology; November 1989, Vol. 14 Issue: 6 p1464-1473, 10p
Abstrakt: Abnormalities of skeletal muscle have been described in patients with dilated and hypertrophic cardiomyopathy. Eleven patients with dilated and eight with hypertrophic cardiomyopathy without overt symptomatic skeletal myopathy underwent extensive neuromuscular studies. Quantitative electromyography showed abnormal reduction of motor unit potential duration, indicative of myogenic myopathy, in four patients (36%) with dilated and in three (37%) with hypertrophic cardiomyopathy. Values were 21% to 40% (mean 28%) lower than those in age-matched normal control subjects. The presence of normal nerve conduction velocities and of normal motor unit fiber density in all patients indicated lack of neurogenic abnormalities.
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