| Autor: |
Takenaka, Katsunobu, Sakai, Hideki, Yamakawa, Hiroyasu, Itoh, Takeshi, Murase, Satoru, Yamakawa, Haruki, Okumura, Ayumi, Nishimura, Yasuaki, Andoh, Takashi, Nakashima, Shigeru, Nozawa, Yoshinori, Sakai, Noboru |
| Zdroj: |
Neurological Research; June 1999, Vol. 21 Issue: 4 p368-372, 5p |
| Abstrakt: |
AbstractThis study is designed to determine whether patients with aneurysmal subarachnoid hemorrhage have mutations in the phospholipase C-dl (PLC-51) gene, which was identified as a gene responsible for hypertension in spontaneously hypertensive rats. Seventy-two cases (31 male and 4 1 female) with intracranial saccular aneurysms were analyzed. The mean age was 60.1 ± 11.5 years (mean± SD) (range 24-85 years). There were 35 patients (48.6%) with hypertension, 5 (6.9%) with diabetes mellitus, 72 (16.7%) with hyperlipidemia, 8 (11.1%) with ischemic heart disease, and 25 (34.7%) who were active smokers. The location of aneurysm was distributed as follows: 33 (33%) were at anterior cerebral artery, 23 (23%) were at middle cerebral artery, 28 (28%) were at internal carotid artery, and 16 (16%) were at vertebro-basilar artery. Six patients (8.3%) had a family history of intracranial aneurysms. There were 20 patients (27.8%) with multiple aneurysms, and 8 patients (11.1 %) with a large or giant aneurysm. The four regions of PLC-51 gene (bases 1099-1271, 1254-1401, 1343-1481, and 1882-2023) where genetic mutations were found in spontaneously hypertensive rats, were screened by PCR-SSCP analysis and their nucleotide sequences of all patients were determined. However, no mutations were detected in all patients. These results suggest that mutations ofPLC-d 1 gene previously implicated in hypertensive factor in rats may not be the case with human patients and therefore may be poorly related with aneurysmal subarachnoid hemorrhage. [Neurol Res 1999; 21: 368-372] |
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