| Autor: |
Thomasson-Perret, Nitza, Pénélaud, Pierre-François, Théron, David, Gouttefangeas, Sylvie, Mocaër, Elisabeth |
| Zdroj: |
Thérapie; May-June 2008, Vol. 63 Issue: 3 p237-242, 6p |
| Abstrakt: |
Positrons Emission Tomography (PET) allows to evaluate the dopaminergic activity of antipsychotic, by measuring post synaptic D2dopaminergic receptors occupancy. A good correlation was brought forward between a rate of occupancy of 80% of striatal D2receptors and the occurrence of extrapyramidal effects. These PET studies have also established that at least 60% D2receptors occupancy was predictive of clinical antipsychotic response. The PET studies in healthy volunteers can then be used to help choose doses to be tested during the clinical trials of new antipsychotic drugs. The increase in prolactin level is one other of the markers of the antagonist dopaminergic activity which concerns D2receptors of the pituitary gland. The example of S 33138, a potential antipsychotic, preferential D3versusD2receptor antagonist will be given to illustrate these data. The results of two PET studies as well as the effects on prolactin and extrapyramidal signs will be presented. |
| Databáze: |
Supplemental Index |
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