Candelalides A−C:  Novel Diterpenoid Pyrones from Fermentations of Sesquicillium candelabrum as Blockers of the Voltage-Gated Potassium Channel Kv1.3

Autor: Singh, S. B., Zink, D. L., Dombrowski, A. W., Dezeny, G., Bills, G. F., Felix, J. P., Slaughter, R. S., Goetz, M. A.
Zdroj: Organic Letters; January 2001, Vol. 3 Issue: 2 p247-250, 4p
Abstrakt: Blockers of the voltage-gated potassium channel Kv1.3 are potential immunosuppressants. Candelalides A−C are three novel diterpenoid pyrones that block this channel. The structure, stereochemistry, and activity against Kv1.3 are described.
Databáze: Supplemental Index
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