| Autor: |
Jagadeesan, V., Rukmini, C., Vijayaraghavan, Malini, Tulpule, P.G. |
| Zdroj: |
Food and Chemical Toxicology; January 1982, Vol. 20 Issue: 1 p83-87, 5p |
| Abstrakt: |
Ingestion of T-2 toxin, a product of Fusarium fungi, has been reported to have a variety of effects leading to morbidity and mortality in animals and humans. Semi-purified T-2 toxin was given to monkeys by gastric intubation at a level of 100 μg/kg body weight/day for 4–5 wk and the haematological and immune parameters were studied before and after the treatment. Leucocyte counts were depressed at the end of wk 4 of treatment. The immunological studies showed suppression of the bactericidal activity of neutrophils, of cell-mediated immune status as assessed by T-cell number and lymphocyte transformation, and of humoral immunity as reflected in B-cell number and IgG and IgM levels. However serum complement (CH50) did not show any change. Investigations carried out 5 months after withdrawal of the toxin indicated that these parameters had returned almost to the initial, pretreatment levels. These data suggest that the greater incidence of infection seen in mycotoxin-ingesting animals may be due to immune suppression. Withdrawal of the mycotoxin results in improvement of haemato logical and immune functions. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
|
