| Autor: |
Frame, Lawrence H., Sheldon, Jeffrey H. |
| Zdroj: |
Journal of the American College of Cardiology; January 1988, Vol. 12 Issue: 3 p746-752, 7p |
| Abstrakt: |
The effect of recainam (WY-42,362), a new class IC antiarrhythmic drug, on ventricular defibrillation was evaluated with use of implanted superior vena cava and left ventricular patch electrodes in 17 normal dogs anesthetized with sodium pentobarbital. The energy required for a 50% probability of successful defibrillation (E50) was used as the index of ventricular defibrillation threshold. The dogs were classified into three groups: a saline group (n = 6), a low dose recainam group (n = 6) and a high dose recainam group (n = 5). The low dose infusion involved an intravenous loading dose of 3.75 mg/kg body weight over 20 min followed by a maintenance infusion of 0.0375 mg/kg per min. The high dose infusion was double those rates. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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