| Autor: |
Pappas, T.N., Debas, H.T., Taylor, I.L. |
| Zdroj: |
Gastroenterology; December 1985, Vol. 89 Issue: 6 p1387-1392, 6p |
| Abstrakt: |
Peptide YY is an ileocolonic peptide that inhibits meal-stimulated pancreatic secretion when infused in a dose of 400 pmol/kg · h. In this study pancreatic secretion was monitored in response to increasing doses of secretin or cholecystokinin-octapeptide (62.5, 125, 250, and 500 ng/kg · h) during the simultaneous infusion of either saline or peptide YY (400 pmol/kg · h). Peptide YY significantly (p < 0.05) inhibited the secretory response to the three lowest doses of each pancreatic secretogogue, reducing the bicarbonate response to the 62.5-ng/kg · h dose of secretin by 86% ± 6% and the protein response to the same dose of cholecystokinin by 57% ± 16%. In the second limb of the study, the half-life of peptide YY (11.7 ± 21 min) and the metabolic clearance rate (13.8 ± 1.6 ml/kg · min) were found to be similar to those of other gastrointestinal hormones. We conclude that inhibition of meal-stimulated pancreatic secretion by peptide YY can be explained by its ability to decrease the responsiveness of the pancreas to endogenous secretogogues. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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