| Autor: |
Burmer, Glenna C., Levine, Douglas S., Kulander, Bruce G., Haggitt, Rodger C., Rubin, Cyrus E., Rabinovitch, Peter S. |
| Zdroj: |
Gastroenterology; August 1990, Vol. 99 Issue: 2 p416-420, 5p |
| Abstrakt: |
Mutations in the first exon of the c-Ki-rasprotooncogene were analyzed in carcinomas and dysplasias from patients with sporadic colon cancer and chronic ulcerative colitis by a combination of histological enrichment, cell sorting, polymerase catalyzed chain reaction, and direct sequencing. In contrast to sporadic colon carcinomas, where 52% (11 of 21) contained mutations in codon 12, only 1 of 28 samples of ulcerative colitis associated carcinoma or dysplasia contained a c-Ki-rasmutation, despite the presence of aneuploid cell populations. These results suggest that a different genetic pathway for tumor progression may exist between sporadic colon carcinoma and carcinomas arising in chronic ulcerative colitis. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
|
