| Autor: |
Bradley, Daniel W., McCaustland, Karen A., Cook, E.H., Schable, Charles A., Ebert, James W., Maynard, James E. |
| Zdroj: |
Gastroenterology; March 1985, Vol. 88 Issue: 3 p773-779, 7p |
| Abstrakt: |
Posttransfusion non-A, non-B hepatitis associated with the formation of hepatocyte cytoplasmic tubules was experimentally transmitted to chimpanzees by intravenous inoculation of a proven-infectious plasma that had been pelleted and microfiltrated, or purified by a combination of pelleting and rate-zonal banding. The results of these studies indicate that a factor VIII-derived non-A, non-B tubule-forming agent will pass through an 80-nm membrane filter and that it can be recovered from infected plasma by use of a purification procedure that assumes the non-A, non-B tubule-forming agent is a small, enveloped virus. Our findings, in combination with the known sensitivity of the non-A, non-B tubule-forming agent to chloroform and its apparent lack of nucleic acid homology with hepatitis B virus, further suggest that at least one etiologic agent of human posttransfusion non-A, non-B hepatitis may be a small, enveloped RNA virus. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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