| Autor: |
Lerch, Markus M., Saluja, Ashok K., Rünzi, Michael, Dawra, Rajinder, Saluja, Manju, Steer, Michael L. |
| Zdroj: |
Gastroenterology; March 1993, Vol. 104 Issue: 3 p853-861, 9p |
| Abstrakt: |
Background:The common channel theory suggests that bile reflux, through a common biliopancreatic channel, triggers acute pancreatitis. In the present study, this controversial issue was evaluated using an experimental model of hemorrhagic necrotizing pancreatitis. Methods:American opossums underwent ligation of the pancreatic duct alone, bile and pancreatic duct separately, or common biliopancreatic duct; the severity of pancreatitis was evaluated at selected times after ligation. Results:Animals in all three experimental groups developed hemorrhagic necrotizing pancreatitis; the severity of pancreatitis was similar in each group, although only those subjected to common biliopancreatic duct ligation experienced bile reflux. Conclusions:Bile reflux into the pancreatic duct, via a common biliopancreatic channel, is not necessary for the development of pancreatitis and does not worsen the severity of pancreatitis associated with pancreatic duct obstruction in this model. |
| Databáze: |
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