On the Introduction of a Trifluoromethyl Substituent in the Epothilone Setting:  Chemical Issues Related to Ring Forming Olefin Metathesis and Earliest Biological Findings

Autor:	Rivkin, A., Biswas, K., Chou, T.-C., Danishefsky, S. J.
Zdroj:	Organic Letters; November 2002, Vol. 4 Issue: 23 p4081-4084, 4p
Abstrakt:	The disclosure herein describes the synthesis of 10,11-dehydro-13,14-desoxy-27-trifluoro-[17]epothilone B via a stereoselective ring-closing metathesis and provides early biological evaluation data pertinent to this compound.
Databáze:	Supplemental Index
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