| Autor: |
Crowther, Roger S, Bellanger, Renee, Szauter, Karen EM |
| Zdroj: |
The Annals of Pharmacotherapy; September 1995, Vol. 29 Issue: 9 p859-864, 6p |
| Abstrakt: |
Objective: To determine the chemical stability and physical compatibility of ranitidine in enteral nutrient formulas.Measurements: A stability-indicating HPLC assay was used to measure the recovery of ranitidine from tablet (dissolved in water) or syrup after up to 24 hours of in vitro incubation in a variety of enteral nutrient formulas. Ranitidine binding to components of the formulas was measured after ultrafiltration.Results: Eight enteral nutrient formulas were studied, and more than 90% of added ranitidine was recovered from each formula after 24 hours. The amount of ranitidine bound to components of the formulas varied between 8% and 29%. No gross physical incompatibilities were seen and the pH of each formula changed by less than 0.1 pH units over 24 hours.Conclusions: Ranitidine from either tablet or syrup was stable in the enteral nutrient formulas studied. Administration of ranitidine by admixture into these enteral formulas may be feasible. |
| Databáze: |
Supplemental Index |
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