| Autor: |
Zhou, Jun, Shi, Ming Xia, Mitchell, Tiffany D., Smagin, Gennady N., Thomas, Sonyja R., Ryan, Donna H., Harris, Ruth B.S. |
| Zdroj: |
Experimental Biology and Medicine; April 2001, Vol. 226 Issue: 4 p312-319, 8p |
| Abstrakt: |
Rats exposed to repeated restraint weigh less than controls even 8 weeks after stress. Stress-induced weight loss is lean tissue, but the post-stress difference in weight between control and restrained rats is lean and fat mass. Whole-body glucose clearance is enhanced 1 day after stress, but adipocyte glucose utilization is inhibited and muscle glucose transport is unchanged. The studies described here demonstrated that glucose transport was increased in both restrained and pair-fed rats, but that glycogen synthesis was increased only in restrained rats, which may account for the improved whole-body glucose clearance. Adipocyte glucose transport was inhibited and adipose plasma membrane β-adrenergic receptor number was increased 1 day post-stress in restrained rats when weight loss was lean tissue, but were not different from control rats 5 days post-stress, when both fat and lean tissue were reduced. Thus, repeated restraint induces reversible changes in adipocyte metabolism that may represent a transition from the catabolic state of stress to a new energetic equilibrium in rats that maintain a reduced body weight for an extended period of time. |
| Databáze: |
Supplemental Index |
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