| Autor: |
DiMauro, E. F., Kozlowski, M. C. |
| Zdroj: |
Organic Letters; October 2002, Vol. 4 Issue: 22 p3781-3784, 4p |
| Abstrakt: |
The first catalytic, enantioselective addition of organozinc reagents to α-ketoesters is described. Modular bifunctional salen catalysts that contain Lewis acid and Lewis base activating groups accelerate the carbonyl addition to a much greater extent than the competing carbonyl reduction. α-Hydroxyesters containing new quaternary stereogenic centers are obtained in high yield and moderate enantiomeric excess. Enrichment to 98% ee can be effected by recrystallization of the corresponding α-hydroxy acid. |
| Databáze: |
Supplemental Index |
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