| Abstrakt: |
There are few reports with respect to the details of acute effects (during and following RT) of ionizing radiation in liver tissue in epidemiology, pathology, physiology and imageology. Therefore, this study was undertaken to assess the diagnostic value of 2-[$${}^{18}\hbox {F}$$ 18F ]-fluoro-2-deoxy-D-glucose positron emission tomography with computed tomography ([$${}^{18}\hbox {F}$$ 18F ]-FDG-PET/CT) in the detection of acute radiation toxicity in normal liver using Tibet minipigs as a model. Thirty-six male Tibetan minipigs were randomly divided into six groups ($$n = 6$$ n=6 ). The irradiation groups were treated with a single dose of $$2, 5, 8, 11 \hbox { and } 14 \hbox { Gy}$$ 2,5,8,11and14Gy total body irradiation using an 8-MV X-ray linac, at dose rate of $$255 \hbox { cGy/min}$$ 255cGy/min . The control group was not irradiated. The pigs were evaluated with [$${}^{18}\hbox {F}$$ 18F ]-FDG-PET/CT, and their alanine aminotransferase (AST) and aspartate aminotransferase (ALT) activities and the ALT/AST ratio, INRatio and bilirubin were measured on Day 7 post-TBI. All pigs were killed on Day 7 post-TBI to collect liver tissues for pathological examination. The results showed that liver standardized uptake value (SUV) increased with the dose from 2 to 11 Gy and decreased suddenly at $$14 \hbox { Gy}$$ 14Gy . HAI score showed a radiation dose-dependent increase of 2–11 Gy and was positively correlated with SUV ($$p<0.05$$ p<0.05 ). However, HAI score showed no correlation with liver function. Therefore, we concluded that [$${}^{18}\hbox {F}$$ 18F ]-FDG-PET/CT has the potential to assess acute radiation-induced hepatic injury on early stage. |
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