| Autor: |
Reyes, Francisco I., Winter, Jeremy S.D., Rochefort, J. Guy, Faiman, Charles |
| Zdroj: |
Fertility and Sterility; November 1977, Vol. 28 Issue: 11 p1175-1178, 4p |
| Abstrakt: |
The effects of luteinizing hormone (LH)-releasing hormone (LH-RH), human chorionic gonadotropin (hCG), and placebo upon the timed induction of ovulation were compared in two double-blind, randomized trials in eight regularly ovulating women with variable menstrual cycle intervals. Each treatment was given 1 or 2days before the earliest estimated time of ovulation based upon previous records of basal body temperature. In 12 of the 28cycles there was evidence (pretreatment LH and progesterone levels) that ovulation had occurred or was imminent prior to treatment. Only 5 of the remaining 16cycles showed a positive response, defined as evidence of ovulation within 48hours after treatment and normal subsequent luteal function. Such positive responses were observed in three cases following treatment with LH-RH, and in one case each following hCG and placebo treatment. In seven cycles evidence of ovulation appeared 3 or more days following treatment, making a response questionable. In four other cycles treatment was followed by a short luteal phase or by ovulation failure; these can be regarded as treatment failures. It is evident that no conclusions as to the relative efficacy of LH-RH or hCG versus placebo as triggers of ovulation can be reached. Furthermore, these results demonstrate that evaluation of efficacy of ovulation-triggering agents in spontaneously ovulating women, in contrast to anovulatory patients, is fraught with difficulty and cannot be made without the concomitant use of appropriate controls. |
| Databáze: |
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