Combined Use of Clomiphene and Intranasal Luteinizing Hormone-Releasing Hormone for Induction of Ovulation in Chronically Anovulatory Women**Supported by Veterans Administration Institutional Research Funds.††Presented at the Thirty-Sixth Annual Meeting of The American Fertility Society, March 18 to 22, 1980, Houston, Texas.

Autor: Phansey, Shaila A., Barnes, Mary A., Williamson, H. Oliver, Sagel, Julius, Nair, R.M.G.
Zdroj: Fertility and Sterility; November 1980, Vol. 34 Issue: 5 p448-451, 4p
Abstrakt: Combined therapy with clomiphene and intranasal luteinizing hormone-releasing hormone (LHRH) was used to induce ovulation in eight chronically anovulatory patients under treatment for infertility. Clomiphene, 100mg daily, was given from the 5th to the 9th day of the cycle. Synthetic LHRH was administered intra nasally in different dosages from day 11 to day 14, in an attempt to induce late follicular development and ovulation. Five of the eight patients ovulated, and three conceived. The success achieved with combined clomiphene and intranasal LHRH administration suggests a therapeutic potential in the management of anovulatory infertility.
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