| Autor: |
Glass, Allan R., Vigersky, Robert A. |
| Zdroj: |
Fertility and Sterility; August 1980, Vol. 34 Issue: 2 p144-148, 5p |
| Abstrakt: |
To assess Leydig cell function in men with idiopathic oligospermia, serum levels of testosterone and 17-hydroxy progesterone were measured before and after the administration of human chorionic gonadotropin (hCG) to men with oligospermia (<20×106sperm/ml). Serum testosterone and 17-hydroxyprogesterone levels, both basally and after 2 or 72 hours of hCG stimulation of Leydig cell output, were the same in the oligospermic and control groups, although basal serum testosterone levels correlated directly with sperm density (r=0.34; P<0.05). The basal serum level of luteinizing hormone (LH) was slightly but significantly higher in the oligospermic group than in the control group (12.0±1.0 [SE] mIU/ml versus 9.5±0.5; P<0.05), as was the LH:testosterone ratio (2.45±0.20 versus 1.74±0.20; P<0.02). The combination of slightly elevated serum LH levels with unchanged basal serum levels of gonadal steroids suggests that men with idiopathic oligospermia have a mild, compensated Leydig cell defect. The mildness of this defect is reflected by the ability of maximal gonadotropic stimulation to increase androgen output. |
| Databáze: |
Supplemental Index |
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