| Autor: |
Sowers, James R., Fayez, Jamil, Colantino, Marta, Jonas, Harry |
| Zdroj: |
Fertility and Sterility; October 1978, Vol. 30 Issue: 4 p403-407, 5p |
| Abstrakt: |
The effect of intra-amniotic administration of prostaglandin F2α(PGF2α) on pituitary hormone release was studied in women undergoing midtrimester abortion. Serum prolactin (PRL), growth hormone (GH), thyrotropin (TSH), luteinizing hormone (LH), and follicle-stimulating hormone (FSH) were measured prior to and at 15-minute intervals for 2hours following intra-amniotic administration of 40 gm of urea alone, 20mg of PGF2αand 40 gm of urea, or an equal volume of normal saline. Serum PRL levels were significantly higher at sampling times from 15 through 120minutes when both PGF2αand urea were administered than after saline or urea alone. The elevation in serum GH following PGF2αand urea was not significantly greater than for urea alone. The GH response in the women receiving normal saline was significantly less than for the two groups of women receiving the abortifacients. These results indicate that the GH response was related to the stress effects of the abortifacients. There was no difference in the TSH, LH, and FSH responses for the three groups. These results suggest that PGF2αselectively causes pituitary release of PRL in women during midtrimester pregnancy. |
| Databáze: |
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