| Autor: |
Blake, Richard E., Rajguru, Shakuntala, Nolan, George H., Ahluwalia, Balwant S. |
| Zdroj: |
Fertility and Sterility; January 1988, Vol. 49 Issue: 1 p66-70, 5p |
| Abstrakt: |
Dexamethasone suppression (DEX-S) for 14days has been used to determine the probable source of androgen excess. The exact mechanism(s) of DEX-S is still unclear. The authors postulated that dexamethasone (DEX) inhibits either the synthesis or secretion of sex-hormone binding globulin (SHBG). To examine this hypothesis, 14 women with polycystic ovarian disease (PCOD) and 3 volunteers were given DEX for 14days. The PCOD group included obese and nonobese women (±15% ideal body weight). Plasma determinations by radioimmunoassay of total testosterone, free testosterone, androstenedione, dehydroepiandrosterone sulfate, luteinizing hormone; follicle-stimulating hormone; cortisol, and SHBG were made. DEX suppressed SHBG levels (P<0.01). SHBG levels were significantly lower in the obese than in the nonobese (P<0.01). All androgens were suppressed by DEX, with the exception of androstenedione post-DEX levels, which were significantly greater than pre-DEX levels in 6 of 14 subjects (P>0.05). This observation is consistent with DEX suppression of SHBG. |
| Databáze: |
Supplemental Index |
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