| Autor: |
Lemay, André, Faure, Nacia, Bastide, Adrien |
| Zdroj: |
Fertility and Sterility; January 1987, Vol. 47 Issue: 1 p60-66, 7p |
| Abstrakt: |
Ovarian ultrasounds were performed in four groups of six or seven women taking intranasal luteinizing hormone-releasing hormone agonist Buserelin (200μg twice daily or 400μg once daily) for periods of 14 or 21days. Medroxyprogesterone acetate (5mg by mouth twice daily) was added on days 15 to 21. A pause of 7days followed each of the four treatment periods. Between days 12 to 15 of the first Buserelin cycle, sonograms showed in 17 cases (68%) various degrees of follicular stimulation ranging from numerous 4- to 10-mm follicles (24%), to 10- to 27-mm developing follicle(s) (24%), to>27-mm ovarian cysts (20%). At the fourth Buserelin cycle, the predominant observation was large follicle(s) in the 14-day schedules, whereas ovarian scans did not reveal follicular stimulation in 66% of the 21-day schedules. The area under estradiol (E2) curves was above control in cycles with induced large follicles mainly in the 14-day schedules at the 200μg/12hour dose. Occasional brief and low elevation of progesterone was compatible with luteinized follicles. In the 21-day schedules at 400μg/24hours, absence of follicular development was frequently associated with serum E2in the early follicular phase range. The most appropriate dosage regimen for potential contraception was 200μg/12hours for 21days because it was associated with small follicles and serum E2was in the range of control cycles. |
| Databáze: |
Supplemental Index |
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