Alternative indications for pulsatile gonadotropin-releasing hormone therapy in infertile women

Autor: Phansey, Shaila A., Toffle, Roger, Curtin, John, Nagel, Theodore C., Tagatz, George E., Barnes, Mary A., Nair, Raghawan
Zdroj: Fertility and Sterility; November 1985, Vol. 44 Issue: 5 p589-594, 6p
Abstrakt: Three groups of women with different types of ovulatory dysfunction who had failed to conceive on conventional therapy were treated with pulsatile gonadotropin-releasing hormone (GnRH). Group A consisted of nine patients with luteal phase defect; group B included four patients with apparently normal menstrual cycles but disordered folliculogenesis seen by serial ultrasound examinations; and group C consisted of eight patients who exhibited anovulation or irregular ovulation. GnRH was administered subcutaneously or intravenously in dosages varying from 5 μg to 20 μg, with pulse frequency of 2 to 3 hours in 53 cycles. Forty-one cycles were ovulatory. Four pregnancies resulted, one ending in miscarriage at 12 weeks’ gestation.
Databáze: Supplemental Index