Pergolide mesylate inhibits exercise-induced prolactin release in man

Autor: De Meirleir, Kenny, Baeyens, Luc, L’Hermite, Marc, L’Hermite-Balériaux, Mireille, Olbrecht, Jan, Holmann, Wilder
Zdroj: Fertility and Sterility; April 1985, Vol. 43 Issue: 4 p628-631, 4p
Abstrakt: The effects of Pergolide, a potent dopamine agonist, on exercise-induced plasma prolactin (PRL) changes were studied in normal men. Exercises consisted of a graded bicycle ergometer test and of a 20-km endurance run. In both circumstances, treatment with Pergolide, when compared with placebo or control values, resulted in a significant suppression of basal PRL (P < 0.001) as well as of exercise-induced PRL increase (P < 0.01). From these experiments it was concluded that augmented levels of PRL in plasma, as seen during or after muscular exercise, are caused by increased pituitary secretion, rather than decreased elimination.
Databáze: Supplemental Index