Preclinical abortions: incidence and significance in the Norfolk in vitro fertilization program**Presented in part at the VIth World Congress of In Vitro Fertilization and Alternate Assisted Reproduction, Jerusalem, Israel, April 2 to 7, 1989.

Autor: Acosta, Anibal A., Oehninger, Sergio, Hammer, Jeffrey, Muasher, Suheil J., Liang, Hong Mei, Jones, Debra L.
Zdroj: Fertility and Sterility; April 1990, Vol. 53 Issue: 4 p673-676, 4p
Abstrakt: Clinical and prognostic significance of preclinical abortions in assisted reproduction is ill defined. Strict diagnostic criteria include a transient and synchronous elevation of serum β-human chorionic gonadotropin (hCG), estradiol, and progesterone levels 13 days after hCG administration, ending in a bleeding episode no more than 14 days after the missed period. The preclinical abortion study group (54 patients, 178 cycles) was compared with matched control groups A (54 patients, 132 cycles) and B (54 patients, 155 cycles), representing normal term pregnancies and all outcomes, respectively. Control group C included the overall population during the study period. The abortion rate per transfer (preclinical abortion and total miscarriage rates) and total pregnancy wastage in the study group were significantly higher; the ongoing pregnancy rate was significantly lower. Preclinical abortion should be considered as a true reproductive failure with similar implications.
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