| Autor: |
Bray, Ronald E., Boe, Roger W., Johnson, Wayne L. |
| Zdroj: |
American Journal of Obstetrics and Gynecology; December 1966, Vol. 96 Issue: 7 p938-942, 5p |
| Abstrakt: |
1.1. The transfer of ampicillin, a new semisynthetic penicillin, into fetal serum and amniotic fluid in therapeutic concentrations has been demonstrated.2.2. Maternal serum levels of ampicillin disappear relatively rapidly after intravenous infusion of sodium ampicillin and are almost gone within 2 hours.3.3. Ampicillin is demonstrable in fetal serum 30 minutes after maternal infusion, reaching equilibration with maternal serum in 1 hour.4.4. The concentration of ampicillin in amniotic fluid of normal gravidas continues to rise up to 8 hours and then slowly declines over the next 19 hours.5.5. A low level of ampicillin appears in amniotic fluid of dead fetuses and reaches maximum concentration at 6 hours, which is approximately one fifth of the maximal concentrations of normal pregnancy with a live fetus.6.6. Active participation by the fetus is suggested as a mechanism in establishing higher levels of ampicillin in amniotic fluid of viable pregnancies, probably by fetal urinary excretion.7.7. Ampicillin shows promise as a useful drug in the treatment of amnionitis and intrauterine fetal sepsis. |
| Databáze: |
Supplemental Index |
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