Serial hormone assays in patients with uteroplacental insufficiency

Autor: Bell, E.T., Loraine, J.A., McEwan, H.P., Charles, D.
Zdroj: American Journal of Obstetrics and Gynecology; February 1967, Vol. 97 Issue: 4 p562-570, 9p
Abstrakt: A detailed study has been made of serial urinary estrone, estradiol, estriol, pregnanediol, and chorionic gonadotropin levels during the latter half of pregnancy in 5 patients with previous unsuccessful pregnancies. The variation observed from day to day emphasize that serial studies were necessary in order to obtain reliable information. At the commencement of the investigation, estrogen and pregnanediol urinary levels were generally within the normal range, but the gonadotropin levels were abnormally low. The pregnanediol/estriol ratios in patients with uteroplacental insufficiency were compared with those reported for normal pregnancy. In the subjects studied the ratio tended to be high throughout, but prior to delivery a marked decrease was noted. It is considered that the changes resulted from differences in the relative contributions of fetus and placenta to the excretion of these metabolites in the maternal urine.
Databáze: Supplemental Index