| Autor: |
Elias, Alan N., Szekeres, Agnes V., Stone, Sergio, Valenta, Lubomir J. |
| Zdroj: |
American Journal of Obstetrics and Gynecology; September 1982, Vol. 144 Issue: 1 p72-76, 5p |
| Abstrakt: |
The effect of di-n-propylacetic acid (valproic acid), a gamma-aminobutyric acid transaminase inhibitor, on the luteinizing hormone (LH) and follicle-stimulating hormone (FSH) response to gonadotropin-releasing hormone (LHRH) was studied in five normal women during the proliferative and luteal phases of the menstrual cycle. Valproic acid produced no significant change in the basal serum concentrations of LH, FSH, estradiol, and progesterone in either the proliferative or the luteal phase of the study. In the proliferative phase the ΔLH (maximum increment above baseline) following LHRH stimulation rose from 32.8 ± 21.2 (mean ± SD) to 52.2 ± 28.7 mlU/ml (not significant) after valproic acid, while the ΔFSH rose from 2.2 ± 1.1 to 5.0 ± 3.6 mlU/ml (not significant). Four of the five volunteers showed an augmentation of the ΔLH response to LHRH after valproic acid while the fifth subject showed no change. In three subjects the augmented ΔLH response after valproic acid was highly significant. By contrast, the ΔLH in the luteal phase following LHRH stimulation fell from 65.3 ± 20.1 to 43.1 ± 12.9 mlU/ml after valproic acid (p < 0.03). Corresponding ΔFSH values were 2.5 ± 1.1 and 2.1 ± 0.8 mlU/ml (not significant). It is speculated that gamma-aminobutyric acid may exert a modulatory role on gonadotropin secretion following LHRH stimulation and that this effect is influenced by the phase of the menstrual cycle. |
| Databáze: |
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