| Autor: |
Gilani, Shamshad H., Jaffee, Oscar C. |
| Zdroj: |
American Journal of Obstetrics and Gynecology; September 1971, Vol. 111 Issue: 1 p47-52, 6p |
| Abstrakt: |
The effects of x-irradiation and hypothermia on cardiovascular development were analyzed in chick embryos. Cardiovascular anomalies produced by x-irradiation and hypothermia included aortic stenosis, common truncus arteriosus, ventricular and atrial septal defects, abnormal semilunar valves, thin ventricular wall, and inhibition of aortic arch development. Aortic stenosis was the most frequent finding at low dosages of radiation while common truncus arteriosus was the most frequent finding at higher levels of radiation. Exposure of the embryos to hypothermia before irradiation had a questionable effect upon radiosensitivity of the embryos (as determined by LD50values) or radiation damage to the developing heart (as determined by the incidence of cardiac defects). Exposure to cold after radiation appeared to exaggerate the effects of the radiation, as determined by an increased sensitivity and a greater incidence of cardiac anomalies. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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