| Abstrakt: |
Three synthetic estrogens, diethylstilbestrol, hexestrol, and 118-B were tested for their therapeutic efficiency by assay in humans. The subjective response of menopausal patients was used as the end point in this assay. The usual uncontrolled factors encountered in such a study were largely eliminated by using multiple dosage levels of the estrogens as well as other precautions. The results indicate that all three synthetic estrogens are highly effective in relieving the distressing symptoms of the menopause if proper dosages are used. A satisfactory daily therapeutic dose of diethylstilbestrol is 1 mg., of hexestrol, 2.5 to 5 mg., and of 118-B, 1 to 2 mg. The larger the dose of synthetic estrogen used, the greater the likelihood of untoward reactions. Hexestrol is definitely less toxic than diethylstilbestrol, and 118-B is far less toxic than either diethylstilbestrol or hexestrol. |
