| Autor: |
Dandavino, A., Woods, J.R., Murayama, K., Brinkman, C.R., Assali, N.S. |
| Zdroj: |
American Journal of Obstetrics and Gynecology; April 1977, Vol. 127 Issue: 7 p769-774, 6p |
| Abstrakt: |
We have studied the effects of magnesium sulfate (MgSO4) administration in chronically instrumented normotensive and hypertensive pregnant sheep. Animals of 90 to 144 days' gestation were divided in two groups: those with normotensive arterial pressure and those in which renovascular hypertension had been produced. Our results show that bolus injection of 2 or 4 Gm. of MgSO4caused a transient decrease in systolic and diastolic pressure which returned to control values within 5 to 10 minutes. The continuous infusion of MgSO4in doses of 2 or 4 Gm. per hour produced a slight increase in uteroplacental blood flow but did not alter the blood pressure. Heart rate showed a slight increase. Because MgSO4produced no significant hemodynamic changes, we feel that: (1) its use in obstetrics must be based on its anticonvulsant action and (2) MgSO4in either normotensive or hypertensive patients is not associated with impairment of uteroplacental blood flow. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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