Nitrogen and phenylalanine mustard

Autor: Diddle, A.W., Watts, Glenn, Watts, Jane, Jenkins, H.H.
Zdroj: American Journal of Obstetrics and Gynecology; February 1962, Vol. 83 Issue: 4 p490-493, 4p
Abstrakt: Thirteen women with either cervical or endometrial carcinoma or choriocarcinoma were given nitrogen or phenylalanine mustard. Leukopenia, pancytopenia, and anemia occurred in varying degrees of severity in different patients; two women died of sepsis during or shortly after the most acute phase of bone marrow depression. A third person acquired permanent partial motor paralysis of both legs from neurotoxic effects. The intrapelvic soft tissues were “frozen” in the fourth patient by the radiomimetic action of nitrogen mustard. Only those with endometrial carcinoma and with an initial favorable prognosis were living 2 years later.
Databáze: Supplemental Index