Hepatocyte specificity for α-foetoprotein production

Autor: Cauchi, M.N., Nairn, R.C.
Zdroj: Pathology; January 1973, Vol. 5 Issue: 1 p39-42, 4p
Abstrakt: The production of antiserum to α-foetoprotein has permitted the localization by immunofluorescence of α-foetoprotein-producing cells in human foetal liver and hepatoma. Foetal hepatic parenchyma, but not adult liver, showed a moderately intense diffuse localization accompanied by more conspicuous accumulation of antigen in scattered cells comprising about 1% of hepatocytes. Antiserum absorption experiments suggest that the latter location is more specific. This specific α-foetoprotein localization was also obtained in the cells of a hepatoma.
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