| Autor: |
Hughes, E.C., Lloyd, C.W., Jones, D., Lobotsky, J., Rienzo, J.S., Avery, G.M. |
| Zdroj: |
American Journal of Obstetrics and Gynecology; April 1954, Vol. 67 Issue: 4 p782-800, 19p |
| Abstrakt: |
1.1. There is no increase in antidiuretic activity of serum during normal and toxemic pregnancy.2.2. “Total corticosteroid” increases throughout pregnancy, reaching a peak before delivery. Freely water-soluble corticosteroid increases throughout pregnancy. A poorly water-soluble material appears during the first trimester and increases until the end of pregnancy, constituting 25 per cent of the corticosteroid.3.3. In toxemia, corticosteroid is considerably increased above the level found in normal pregnant women at the same stage of pregnancy. The poorly water-soluble component is also considerably increased above that seen in the normal, respresenting approximately 35 per cent of the total corticosteroid. In one patient with eclampsia, paper chromatography demonstrated a material which has a rate of flow characteristic of 3-oxygen-containing steroids.4.4. The possibility that this material might play a part in the etiology of eclampsia is discussed.5.5. The placental steroid increases during pregnancy, while the levels of chorionic gonadotrophin remain at a low level.6.6. These steroids together with the adrenal steroids may affect the general metabolism of the body and also may sensitize the kidneys so that added factors, perhaps from the placenta, may extend the lesions in these organs so that the function of the kidneys is temporarily altered. Prolonged action of all factors may permanently damage the kidneys.7.7. Reversed excretion of placental hormones during the latter months of pregnancy is noted in toxemia, and may reflect failing placental physiology.8.8. These studies have significant clinical application and direct our attention to the fact that sodium chloride, particularly, should be restricted as early in the gestation as the one hundred twentieth day. |
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