| Autor: |
Yeomans, N.D., St John, D.J.B. |
| Zdroj: |
Pathology; January 1975, Vol. 7 Issue: 1 p35-44, 10p |
| Abstrakt: |
Rats were rendered iron deficient by a combination of diet and bleeding to study its effects on vitamin B12absorption. Small intestinal loops were isolated in vivoand the absorption of 57Co-vitamin B12bound to a known quantity of intrinsic factor was measured. Iron deficiency resulted in the impairment of both uptake and transport of B12. This malabsorption was corrected within 5 days by parenteral iron repletion. The findings were not due to a non-specific effect of anaemia since no correlation existed between haemoglobin levels and B12absorption in rats anaemic as a result of acute blood loss. No evidence was found for an altered small-intestinal microflora, bacterial counts being similar in iron-deficient and control rats. It is concluded that iron deficiency in the rat results in impaired absorption of B12by the small intestine, probably as a result of some defect produced in the enterocyte. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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