| Autor: |
Weisman, Stephen A., Simon, Norman M., Herdson, Peter B., Franklin, Wilbur A. |
| Zdroj: |
American Journal of Obstetrics and Gynecology; December 1973, Vol. 117 Issue: 7 p867-883, 17p |
| Abstrakt: |
Six primigravid women developed the nephrotic syndrome in pregnancy during a 4 year period of observation, including 12,707 deliveries. Clinical evaluation and examination of renal tissue by light and electron microscopy were carried out in each case. Four of the initial pregnancies ended with the delivery of viable infants. Four subsequent pregnancies also terminated successfully. A variety of morphologic lesions was found, including diffuse membranous glomerulonephritis, poststreptococcal glomerulonephritis, and pre-eclampsia. Four patients were followed from 1 to 4 years after delivery. Three women showed minimal clinical and histologic evidence of renal disease at the end of the follow-up period, although one with morphologic abnormalities of pre-eclampsia relapsed transiently 9 months post partum. The fourth patient with an initial kidney biopsy specimen compatible with pre-eclampsia progressed into end-stage renal failure. The findings suggest that the histologic characteristics of pre-eclampsia may not be specific but may be associated with other renal diseases occurring during pregnancy. |
| Databáze: |
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