Effect of some oral contraceptive steroids on the development of endometrial squamous metaplasia and cysts in rats

Autor: Liu, Frank T.Y., Lin, Hsien S., Burich, Raymond L., Wagner, Joseph E.
Zdroj: American Journal of Obstetrics and Gynecology; November 1972, Vol. 114 Issue: 5 p685-690, 6p
Abstrakt: Female rats were injected subcutaneously with 50 μg of norethynodrel plus 2 μg of mestranol per 100 grams of body weight per day for 13 weeks. Controls were treated identically with vehicle alone. These contraceptive steroid treatments caused a significant increase in the incidence of endometrial squamous metaplasia and cyst formation. Treated rats had smaller ovarian and body weights but larger uteri with more luminal fluid than the controls.
Databáze: Supplemental Index