| Autor: |
Woodworth, Mollie B., Greig, Luciano C., Liu, Kevin X., Ippolito, Gregory C., Tucker, Haley O., Macklis, Jeffrey D. |
| Zdroj: |
Cell Reports; May 2016, Vol. 15 Issue: 5 p999-1012, 14p |
| Abstrakt: |
The molecular linkage between neocortical projection neuron subtype and area development, which enables the establishment of functional areas by projection neuron populations appropriate for specific sensory and motor functions, is poorly understood. Here, we report that Ctip1controls precision of neocortical development by regulating subtype identity in deep-layer projection neurons. Ctip1is expressed by postmitotic callosal and corticothalamic projection neurons but is excluded over embryonic development from corticospinal motor neurons, which instead express its close relative, Ctip2. Loss of Ctip1function results in a striking bias in favor of subcerebral projection neuron development in sensory cortex at the expense of corticothalamic and deep-layer callosal development, while misexpression of Ctip1in vivo represses subcerebral gene expression and projections. As we report in a paired paper, Ctip1also controls acquisition of sensory area identity. Therefore, Ctip1couples subtype and area specification, enabling specific functional areas to organize precise ratios of appropriate output projections. |
| Databáze: |
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