| Autor: |
Steer, David, Lew, Rebecca, Perlmutter, Patrick, Smith, A.Ian, Aguilar, Marie-Isabel |
| Zdroj: |
Letters in Peptide Science; May 2001, Vol. 8 Issue: 3-5 p241-246, 6p |
| Abstrakt: |
The use of ß-amino acids as peptidomimetics has emerged in recent years with significant potential in a number of applications. The incorporation of ß-amino acids has been successful in creating peptidomimetics that not only have potent biological activity, but are also resistant to proteolysis. This article reviews the recent applications of ß-amino acids in the design of protease and peptidase inhibitors. Given their structural diversity, together with the ease of synthesis and incorporation into peptide sequences using standard solid-phase peptide synthesis techniques, ß-amino acids have the potential to form a new platform technology for peptidomimetic design and synthesis. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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