A New Fluorescent Chemosensor for Copper Ions Based on Tripeptide Glycyl−Histidyl−Lysine (GHK)

Autor: Zheng, Y., Huo, Q., Kele, P., Andreopoulos, F. M., Pham, S. M., Leblanc, R. M.
Zdroj: Organic Letters; October 2001, Vol. 3 Issue: 21 p3277-3280, 4p
Abstrakt: A new fluorescent chemosensor for Cu2+ ions was synthesized by modifying the tripeptide glycyl−histidyl−lysine (GHK) with 9-carbonylanthracene via the standard Fmoc solid-phase peptide synthesis method. While significant fluorescence quenching was observed from the molecule upon binding with Cu2+, addition of Fe2+, Co2+, Ni2+, and Zn2+ to the peptide solution caused a minimum fluorescence emission spectral change, indicating a high specificity of this chemosensor for Cu2+ ions. Effects of pH were also investigated.
Databáze: Supplemental Index