| Autor: |
Wender, P. A., Jessop, T. C., Pattabiraman, K., Pelkey, E. T., VanDeusen, C. L. |
| Zdroj: |
Organic Letters; October 2001, Vol. 3 Issue: 21 p3229-3232, 4p |
| Abstrakt: |
Short oligomers of arginine function as remarkably efficient molecular transporters of drugs and probe molecules into cells and tissue. Currently, these compounds are prepared on resin through a unidirectional solid-phase synthesis. To extend the utility of these compounds for therapeutic and research applications, a scalable solution-phase synthesis of Arg8 (1) has been developed on the basis of a segment doubling strategy that proceeds in 13 steps and 28% overall yield from 4, including a novel one-step perdeprotection−perguanidinylation reaction. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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