| Autor: |
Guillan, Ramon A., Smalley, Robert L., Zelman, Samuel |
| Zdroj: |
Chest; July 1972, Vol. 62 Issue: 1 p62-65, 4p |
| Abstrakt: |
Electron microscopic study of the hearts of rabbits given short-term high dosages of chlorpromazine revealed changes similar to those found in phenothiazine-treated human subjects who died suddenly. These consisted of severe mitochondrial pleomorphism, loosening of myocardial fiber structure, and intracytoplasmic edema. Widening of Z-band spaces also occurred, as in the human hearts, suggesting incomplete cardiac contraction. A direct effect of phenothiazine drugs on mitochondrial structure and function is suggested and, if sufficiently widespread or strategically located, this effect can trigger changes in cardiac rhythm. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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