Urine Galactomannan-to-Creatinine Ratio for Detection of Invasive Aspergillosis in Patients with Hematological Malignancies

Autor: Reischies, Frederike M. J., Raggam, Reinhard B., Prattes, Juergen, Krause, Robert, Eigl, Susanne, List, Agnes, Quehenberger, Franz, Strenger, Volker, Wölfler, Albert, Hoenigl, Martin
Zdroj: Journal of Clinical Microbiology; December 2015, Vol. 54 Issue: 3 p771-774, 4p
Abstrakt: ABSTRACTGalactomannan (GM) testing of urine specimens may provide important advantages, compared to serum testing, such as easy noninvasive sample collection. We evaluated a total of 632 serial urine samples from 71 patients with underlying hematological malignancies and found that the urine GM/creatinine ratio, i.e., (urine GM level × 100)/urine creatinine level, which takes urine dilution into account, reliably detected invasive aspergillosis and may be a promising diagnostic tool for patients with hematological malignancies. (This study has been registered at ClinicalTrials.gov under registration no. NCT01576653.)
Databáze: Supplemental Index