| Autor: |
Hackmon, Rinat, Blichowski, Monica, Koren, Gideon |
| Zdroj: |
Journal of Obstetrics and Gynaecology Canada; November 2012, Vol. 34 Issue: 11 p1077-1086, 10p |
| Abstrakt: |
Hyperthyroidism is one of the most common endocrine disorders in pregnant women, and it can severely complicate the course and outcome of pregnancy. Methimazole (MMI) and propylthiouracil (PTU) are the standard anti-thyroid drugs used in the treatment of hyperthyroidism in pregnancy. Traditionally, MMI has been considered to have clearer evidence of teratogenicity than PTU. Recent studies suggest that PTU can be hepatotoxic, leading to a United States Food and Drug Administration “black box alert.” We wished to systematically review the effects of PTU and MMI during pregnancy, and to compare maternal and fetal safety. |
| Databáze: |
Supplemental Index |
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