| Autor: |
Doreth, Maria, Löbmann, Korbinian, Grohganz, Holger, Holm, René, Lopez de Diego, Heidi, Rades, Thomas, Priemel, Petra A. |
| Zdroj: |
Journal of Drug Delivery Science and Technology; August 2016, Vol. 34 Issue: 1 p32-40, 9p |
| Abstrakt: |
Previously, the concept of in situamorphization of indomethacin/Eudragit® E compacts was introduced. In the current study, in situamorphization of naproxen and ibuprofen with Eudragit® E was investigated to gain a better understanding of in situamorphization and to investigate if this approach is applicable to other drugs. Compacts of drug and Eudragit® E were compressed at a 2:1, 1:1 and 1:2 drug-to-polymer ratio (w/w) and immersed in water for 1 h. Physicochemical characteristics, potential interactions and dissolution behavior were analyzed and compared to non-immersed compacts. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
|
Full Text from ScienceDirect