Extended pre-exposure prophylaxis with lopinavir–ritonavir versus lamivudine to prevent HIV-1 transmission through breastfeeding up to 50 weeks in infants in Africa (ANRS 12174): a randomised controlled trial

Autor: Nagot, Nicolas, Kankasa, Chipepo, Tumwine, James K, Meda, Nicolas, Hofmeyr, G Justus, Vallo, Roselyne, Mwiya, Mwiya, Kwagala, Mary, Traore, Hugues, Sunday, Amwe, Singata, Mandisa, Siuluta, Chafye, Some, Eric, Rutagwera, David, Neboua, Desire, Ndeezi, Grace, Jackson, Debra, Maréchal, Valérie, Neveu, Dorine, Engebretsen, Ingunn M S, Lombard, Carl, Blanche, Stéphane, Sommerfelt, Halvor, Rekacewicz, Claire, Tylleskär, Thorkild, Van de Perre, Philippe, Van de Perre, Philippe, Nagot, Nicolas, Vallo, Roselyne, Marechal, Valerie, Peries, Marianne, Neveu, Dorine, Foulongne, Vincent, Segondy, Michel, Blanche, Stephane, Treluyer, Jean-Marc, Hirt, Deborah, Tumwine, James K, Ndeezi, Grace, Karamagi, Charles, Musoke, Philippa, Mugaba, Proscovia M, Kwagala, Mary, Murungi, Joan, Muweesi, Hawa Nabuuma, Ninsiima, Evelyn, Baryeija, Simon, Juma, Frederic, Kata, Caleb Bwengye, Katushabe, Stuart, Meda, Nicolas, Ouédraogo, Rasmata, Yé, Diarra, Somé, Eric, Traoré, Hugues A, Nadembega, Christelle, Konaté, Justin, Zongo, Arsène, Ouédraogo, Abass, Néboua, Désiré, Bélemviré, Aissatou, Bambara, Armel, Boncoungou, Justine, Zoungrana, Danielle, Nikodem, Cheryl, Hofmeyr, Justus, Harper, Kim, Jackson, Debra, Sanders, David, Singata, Mandisa, Aku, Amwe, Okegbe-Eze, Collins, Williams, Xoliswa, Mshweshwe, Nolundi, Henge, Vatiswa, Gomba, Fikiswa, Gundu, Tapiwa, Khondowe, Oswell, Kankasa, Chipepo, Mwiya, Mwiya, Lusaka, Mildred, Chizyuka, Mary, Phiri, Mary, Imakando, Billies, Musaku, Mwenechanya, Kapasa, Monica, Rutagwera, David, Clement, Gondwe, Mwaba, Hilton Mwila, Matoba, Japhet, Siuluta, Chafye, Chola, Katai, Mwamutanda, Patricia, Tylleskär, Thorkild, Sommerfelt, Halvor, Engebretsen, Ingunn, Klungsøyr, Jørn, van den Broeck, Jan, Blume, Jörn, Rekacewicz, Claire
Zdroj: The Lancet; February 2016, Vol. 387 Issue: 10018 p566-573, 8p
Abstrakt: Strategies to prevent postnatal mother-to-child transmission of HIV-1 in Africa, including infant prophylaxis, have never been assessed past 6 months of breastfeeding, despite breastfeeding being recommended up to 12 months after birth. We aimed to compare the efficacy and safety of infant prophylaxis with the two drug regimens (lamivudine or lopinavir–ritonavir) to prevent postnatal HIV-1 transmission up to 50 weeks of breastfeeding.
Databáze: Supplemental Index